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Cancer Genomics “Hands-On” Workshop

11th Floor MCC Main Conference Room

Cancer Genomics “Hands-On” Workshop

For Residents, Fellows, and Faculty who are interested in learning about Genomics in Medicine

December 21, 2018

Noon to 4:00 pm

11th Floor MCC – Main Conference Room Program Outline
Course Faculty  Ramaswamy Govindan M.D. – Director, Section of Medical Oncology, Washington University School of Medicine

 Richard Haspel, M.D., Ph.D. – Director of Medical Education, Department of Pathology, Beth Israel Deaconess Medical Center

 Obi Griffith Ph.D. – Assistant Professor of Medicine, Assistant Director of the McDonnell Genome Institute, Washington University School of Medicine

 Jonathan Heusel M.D, Ph.D. – Professor of Pathology and Genetics, Director, Clinical & Translational Genomics, Washington University School of Medicine

Overall Structure Each exercise consists of:

1. An instructor-delivered 15-30 minute PowerPoint lecture to relay content needed to undertake the team-based learning (TBL) activity.

2. A 45-60 minute activity consisting of teams of 3-6 participants working together to answer a series of clinically relevant questions including some necessitating the use of online genomic tools.

3. An instructor-delivered 15-30minute PowerPoint lecture presenting answers to the questions and incorporating a discussion of team responses

Introduction to Workshop and Lunch 12:00 – 12:30pm
Exercise 1

Cancer Gene Panels: Methods and Application Objectives

12:30 – 1:30pm

1. Describe the process for selecting a cancer gene panel.

2. Describe different methods for detecting DNA variants (targeted PCR vs. Sanger-based vs. NGS-Based)

3. Use online tools to interpret the clinical significance of genomic data

4. Determine appropriate clinical trials based on cancer gene panel data

Break 1:30 – 1:45pm
Exercise 2

Cancer Gene Panels:

Result Interpretation and Clinical Utility Objectives

1:45 – 2:45pm

1. Describe key aspects to discuss with patients prior to genomic analysis

2. Describe the process of NGS data analysis

3. Describe the benefits and limitations of integrative genomic analyses for advanced cancer patients

4. Describe the reporting issues related to germline findings

5. Use online tools to interpret the clinical significance of genomic data

Questions/Panel Discussion 2:45 – 3:15pm