The Clinical Research Training Center (CRTC), a component of the Washington University Institute of Clinical and Translational Sciences (ICTS), provides a cohesive and supportive infrastructure to foster clinical research training and career development for predoctoral students, house-staff, postdoctoral fellows and faculty. Active mentoring, hands on research experiences and formal didactic programs in clinical research methods leading to a certificate or Masters Degree in Clinical Investigation are core components of the program. The CRTC represents a paradigm shift in the approach to clinical research training for ICTS institutional partners by formally integrating dozens of diverse training programs into a single location and administrative umbrella.