Clinical Research Training Center (CRTC)

Master of Science in Clinical Investigation (MSCI)

The Master of Science in Clinical Investigation (MSCI) at Washington University is designed as a one to three year full- or part-time degree program for young investigators committed to pursuing academic careers in clinical research.  The unique program combines didactic coursework with mentored research and career development opportunities and provides students with the knowledge and tools to excel in the areas of clinical investigation most relevant to their careers.  Individuals who participate in a CRTC training program (i.e. Postdoctoral MTPCI, KL2, TL1 Intensive, or K12) are eligible to pursue the MSCI degree as their didactic course of study and do not need to complete a separate application. The MSCI is also available as a stand-alone program to individuals not participating in a CRTC training program.  

Applications are open September 15-November 1 for January start date, and January 1-May 1 (must apply by March 15th if participating in MTPCI program) for Summer or Fall start date. 

The MSCI is a 33-credit degree program.  Students of the program:

  • Engage in high-quality didactic courses with mentored research and a weekly multidisciplinary seminar to meet the needs of clinicians seeking training in clinical research.
  • Gain knowledge in the core competencies of clinical research and investigation such as study design, research implementation, statistical approaches, responsible conduct of research, community engagement, scientific communication and literature critique, and leadership.
    • Sample courses include: Introductory and Intermediate Statistics, Designing Outcomes and Clinical Research, Epidemiology, Scientific Writing, Grantwriting, and Ethical and Legal Issues in Clinical Research.
  • May pursue one of three concentrations: Translational Medicine, Genetics/Genomics, or Clinical Investigation. Each concentration provides focused training that is tailored specifically to a student’s interest within clinical and translational research.
  • Attend a weekly, multidisciplinary seminar in order to learn about alternative research designs and methods through the discussion and presentation of peers’ research and obtain key feedback from senior faculty and peers with expertise in their field
  • Attend monthly career development sessions to learn best practices in areas critical to success in clinical research including: grant writing, data management, intellectual property management, budgeting, ethics and other areas.
  • Complete a thesis requirement consisting of a manuscript of original clinical research submitted for publication.
  • Participate in a formal, structured mentorship program that offers an opportunity to work alongside faculty renowned for their innovative clinical research and teaching experience.
  • May enroll full or part-time to accommodate clinical schedules at any point in a career.
  • New alternate entrepreneurial thesis option includes the following:
    • Grant application (e.g. SBIR/STTR), funding proposal, business plan, or peer-reviewed manuscript submission related to a historical analysis of medical device or drug class.
    • Presentation of thesis to an appropriate funding mechanism (e.g. NIH, Bear Cub, Skandalaris Center Cup, Social Entrepreneurship and Innovation Competition, Global Impact Wards, Gates Foundation) or submission to a peer-reviewed journal.
    • An entrepreneurial externship experience with a mentor experienced in the field.
    • Completion of 6 credits of entrepreneurial related electives.
  • Benefits

    • Access to a multidisciplinary pool of highly qualified mentors who will guide research projects and career development.
    • As an MSCI student, you will have access to the Clinical Research Training Center. The Center provides computer labs, break-out rooms, a classroom, poster printing, and administrative office suites.

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  • Program Requirements

    Didactic Coursework

    All MSCI Scholars must complete 33 credit hours of didactic coursework, including sixteen core credits, four credits of MTPCI Research Seminar, at least six credits of electives and variable credits of mentored independent research. For additional information about the specific courses required for each of the concentrations, please see the MSCI Concentrations.


    Scholars will form a thesis committee consisting of three faculty members and will meet with them at least twice per year. The thesis committee should include the scholar's primary mentor, the MSCI Program Director, and a third faculty member in a closely related research field.  The committee meetings will consist of reviewing the scholar’s plan for completing and publishing a research project and manuscript. Scholars will return signed Mentorship Committee forms to the CRTC by December 1st and May 1st.  The final approval meeting will consist of a formal 15-minute presentation of the research followed by the committee’s discussion of the manuscript. See thesis guidelines for more detail. The thesis must be based on original human research conducted during the period of pursuit of the degree.

    Alternate entrepreneurial thesis option also available. See entrepreneurial thesis summary for more details.

    CRTC Seminar

    Scholars are required to attend the weekly CRTC Seminar (currently held on Tuesday afternoons) during the Fall and Spring semesters (mid-August through May). During their first and second years of the Program, scholars are required to present research-in-progress once each year. Feedback will be provided by the Directors, Mentors and peers in attendance. The second week of each month will be dedicated to Career Development topics. During these seminars, speakers will be invited from outside the MSCI Program to present.


    Developing a successful clinical and translational research career requires strong relationships with mentors and a research team. Each Scholar must have a program-approved primary research mentor. This mentor will be the Scholar’s main source of research supervision and career development. It is expected that Scholars will meet weekly with their mentor and that the mentor will be available for consultation and support concerning the Scholar’s current projects and future progress. The mentor is expected to provide formal feedback to the scholar at least semi-annually. In addition to the Scholar’s research mentor, the MSCI Program Director will serve as a mentor to the scholar to further assist in each Scholar’s Career Development during the Program.

    Responsible Conduct of Research (RCR)

    Scholars are required to complete the course Ethical and Legal Issues in Clinical Research (M17-510) during their time in the program as part of their training in the Responsible Conduct of Research.

    IRB Approvals

    Scholars are required to obtain IRB approval for all research conducted as part of their MSCI degree and to provide documentation of current IRB approvals for their research project(s) to the MSCI Program.

    Career Development Plans

    MSCI Scholars must develop a Career Development Plan in consultation with their mentors and must submit the plan by September 15th each year. The plan should include career development goals for the next 1-5 years, career objectives for each goal, research activities/projects that will assist the Scholar in meeting the objectives, and an overview of the courses, workshops and other educational/training activities that the Scholar plans to pursue. For each objective, the Scholar should indicate what individual products (degrees, publications, presentations, grants, etc.) are expected. A timeline should be constructed to display the individual objectives, educational activities, research activities and products.

    Career Development Retreat

    All MSCI scholars are required to attend the annual Retreat hosted by the CRTC. During the late-afternoon event, speakers will highlight topics of relevance to Scholars’ Career Development and Research.

    Research Training Symposium and Poster Session

    In October of each year, the Washington University School of Medicine hosts a school-wide, half day Research Training Symposium and Poster session. All MSCI scholars in their second year and beyond are required to submit an abstract and present a poster.

    Program Evaluation

    Scholars are expected to complete required Program evaluations twice per year. These evaluations are administered online and are mandatory for all Scholars. Scholars are also required to complete an exit interview one month prior to completing their degree.

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  • Eligibility

    Level of Education

    MSCI candidates must either be enrolled in a pre- or post-doctoral mentored research program at Washington University School of Medicine or hold a post-doctoral appointment in health science at Washington University or one of the ICTS affiliates.


    Eligible applicants must be citizens or non-citizen nationals of the United States, or have been lawfully admitted to the United States for permanent residence and have in their possession an Alien Registration Receipt Card (I-151 or I-551) or other legal verification of admission for permanent residence. Individuals on temporary or student visas are eligible provided that they hold a valid US visa and a postdoctoral appointment at Washington University or one of the ICTS affiliates. The MSCI program is unable to sponsor visas. Typically, students who desire to enter the program obtain a visa sponsored through their research department.


    Applicants must have an established relationship with a senior faculty member prior to beginning the MSCI program. Applicants should look for mentors that match their research interests. You should contact each mentor you are interested in working with directly stating your interest in their research and your desire to work with them. Suggested mentors can be found under profiles. If you are having problems finding a mentor, please contact us.

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  • Apply

    Applications are open September 15-November 1 for January start date, and January 1-May 1 for Summer or Fall start date.

    Seven items needed for a complete application:

    1. Application form (
    2. Current Biosketch or CV
    3. Career Development Plan
    4. Research Plan
    5. Mentor Letter of Support
    6. Department Chair or Division Chief Recommendation Letter
    7. Official Transcripts

    Only complete applications will be reviewed.  Applications will not be considered complete until all supporting documents have been submitted.  All application materials must be submitted online. Supporting documents may be updated and resubmitted online prior to the application deadline.  Please note that the selection committee will only receive the latest version of each document that is uploaded to the online site.  Applicants may also attach notes within the online application system after the application form has been submitted if they wish to include additional information (i.e. awards, publications, etc.) for consideration during the selection process.

    Current Biosketch or CV

    Each applicant is required to submit a current CV or NIH Biosketch. Click here for the NIH Biosketch Template.

    Career Development Plan

    A three-page career development plan (references are not included in the page count) should include, but is not limited to the following:

    • Career Goals
    • Past Research Experience and relevant past graduate coursework
    • Research mentor(s) and why they have been selected
    • Planned coursework to be taken during the MSCI, and how this coursework is beneficial to the identified research project

    Research Plan

    The required Research Plan should follow the standard NIH format, and should be no more than 5 pages in length.  Please note that references are not included in the page count, and appendices are not allowed.  The NIH format may be found at

    The NIH research plan format includes:

    • Specific Aims
    • Research Strategy (Significance, Innovation and Approach)
    • Bibliography and References Cited / Progress Report Publication List (include PMCID # if applicable)
    • Protection of Human Subjects
    • Targeted / Planned Enrollment Table
    • Inclusion of Children
    • Vertebrate Animlas
    • Select Agent Research
    • Mutliple PD/PI Leadership Plan
    • Consortium / Contractual Arrangements
    • Letters of Support (e.g. Consultants)
    • Resource Sharing Plan(s)
    • Inclusion of Women and Minorities

    Mentor Letter of Support

    Proposed mentors are required to submit a letter of support. Applicants must establish a relationship with the proposed mentor prior to submission of the MSCI application. Please do not select a mentor without his/her prior approval.

    The proposed mentor must provide a letter of support by the application deadline. Upon submission of the online application form, an e-mail will be automatically generated to the mentor with guidelines and instructions on how to upload the required letter. It is the responsibility of the applicant to verify that the identified mentor has received the e-mail. Applicants may view a confirmation of the documents that have been uploaded via the online application site.

    Department Chair Recommendation Letter

    Each applicant's Department Chair or Division Chief is required to submit a letter of support describing the applicant's potential. This letter of support must be uploaded by the application deadline. Upon submission of the online application form, an e-mail will be automatically generated to the identified Department Chair or Division Chief with guidelines and instructions regarding how to upload the required letter. It is the responsibility of the applicant to verify that the identified reference has received the e-mail. The online application site provides applicants with a checklist on which they may view confirmation of the documents that have been uploaded to their application.

    Letters of recommendation must:

    • Be uploaded by the Department Chair or the Division Chief and not by the applicant
    • Include the Department Chair or the Division Chief's signature
    • Be submitted on letterhead

    Required Format for Supporting Documents

    • Black font of either Arial, Helvetica, Palatino Linotype or Georgia
    • Font size of 11 points or larger (a symbol font may be used to insert Greek letters or special characters; the font size requirement sill applies)
    • Type density, including characters and spaces, must be no more than 15 characters per inch
    • Single spaced paragraph type
    • Margins should be at least one-half inch margins (top, bottom, left, and right) for all pages, including continuation pages
    • PDF versions are encouraged for supporting documents to preserve page limits and formatting
    • Appendices are not allowed

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Apply Today!

Review eligibility requirements for the CRTC program of your choice and complete and submit your application online today.

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St. Louis, MO 63110-1093
Phone: 314.454.8224
Fax: 314.454.8279
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